FACTORS INFLUENCING THE RESPONSE OF ISOLATED DOGFISH SKIN MELANOPHORES TO MELANOCYTE-STIMULATING HORMONE

Y2-Melanocyte-Stimulating Hormone

Peptides of the pro-opiocortin class produce pronounced cardiovascular and natriuretic actions. We have investigated the acute cardiovascular effects of one of the most potent members of this class, y2-melanocyte stimulating hormone (y2-MSH), in rats. Pressor actions of y2MSH administered systemicaMy were eliminated by ganglionic blockade with chlorisondamine. Peripheral cholinergic blockade fa...

Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance

OBJECTIVE Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy b...

-Melanocyte-Stimulating Hormone Inhibits Allergic Airway Inflammation

The experimental generation of antibodies to alpha-melanocyte stimulating hormone and adrenocorticotropic hormone.

Sensitivity, reproducibility, and specificity are requirements for a suitable assay for hormones. The quantitation of a-MSH 1 is currently based on a technique devised in 1954, which utilized isolated pieces of frog skin (1). In the presence of a-MSH, frog skin darkens with a measurable decrease in the reflection of light from the skin. Although this assay possesses great sensitivity (less than...

Alpha-melanocyte-stimulating hormone attenuates behavioral effects of corticotropin-releasing factor in isolated guinea pig pups.

During a 3-hr period of social isolation in a novel environment, guinea pig pups exhibit an initial active phase of behavioral responsiveness, characterized primarily by vocalizing, which is then followed by a stage of passive responsiveness in which pups display a distinctive crouch, eye-closing, and extensive piloerection. Prior treatment of pups with alpha-melanocyte-stimulating hormone (alp...